No need for those Thanksgiving leftovers to go to waste—transform them into the ultimate Thanksgiving Leftover Turkey Sandwich, layered with tender turkey, salty prosciutto, creamy brie and a bright spoonful of cranberry sauce.

Thanksgiving has ended, guests have left, and your fridge is full of cooked turkey, jars of homemade cranberry sauce and more containers of leftovers than you can count. Instead of letting all that good food sit forgotten, make an easy, flavorful sandwich that elevates simple leftovers into something special. This sandwich is quick to assemble, satisfying, and perfect for using up leftover turkey without having to cook another full meal.
The key to a great sandwich is thoughtful layering. I like to start with hearty whole wheat or sprouted bread—lightly toasted for texture—then spread a generous layer of cranberry sauce on both slices. Add slices of leftover turkey and a few slices of prosciutto for a salty contrast. Top the meat with creamy brie that’s been softened just slightly (I warm it 5–10 seconds in the microwave to make it spreadable), then finish with a handful of peppery arugula and a sprinkle of salt and black pepper. Each bite balances sweet, salty, creamy and bright flavors.

How to Make a Leftover Turkey Sandwich
Assemble this sandwich in minutes. Use good-quality bread and assemble the layers thoughtfully so textures and flavors complement each other. Below are simple steps and a short ingredient list so you can make this quickly on a busy post-holiday day.
Suggestions and variations
- If you prefer a warm, melty version, press the sandwich on a grill pan or panini press until the bread is golden and the brie is melted.
- Swap arugula for baby spinach or watercress if you prefer a milder green.
- If you don’t have brie, a soft goat cheese or Camembert works well. For a budget-friendly option, use a mild melting cheese like havarti.
- Toss in a thin layer of Dijon mustard or add a smear of mayonnaise for extra richness.
Thanksgiving Leftover Turkey Sandwich — Recipe
Thanksgiving Leftover Turkey Sandwich
Turn leftover turkey into a decadent sandwich with cranberry sauce, prosciutto, creamy brie and fresh arugula. Ready in about 10 minutes.
Prep Time: 10 mins
Total Time: 10 mins
Servings: 2 sandwiches
Ingredients
- 4 slices whole wheat or sprouted bread
- 1/4 cup cranberry sauce or jam
- 6–8 slices cooked turkey breast
- 4–6 slices prosciutto
- 4 ounces creamy brie, slightly softened
- Handful of arugula
- Salt and black pepper, to taste
Instructions
- Toast the bread lightly if desired. Spread cranberry sauce evenly on each slice of bread.
- Layer slices of turkey breast on two of the bread slices, then add the prosciutto on top of the turkey.
- Warm the brie for 5–10 seconds in the microwave just until it softens enough to spread. Spread a thin layer of softened brie over the turkey and prosciutto.
- Top with a generous handful of arugula and season with a pinch of salt and freshly ground black pepper if desired. Close the sandwich, slice in half, and serve immediately.
This makes an easy lunch or a hearty snack after the holiday. It’s a great way to highlight the flavors of Thanksgiving without any extra cooking.

More Holiday Side Dish Ideas
- Sausage, Apple and Herb Stuffing
- Holiday Glazed Acorn Squash with Pomegranates and Toasted Pine Nuts
- Cranberry Cocktail Meatballs
- Winter Kale & Quinoa Salad
- The Perfect Holiday Cheeseboard
- Lightened Up Green Bean Casserole
I hope you enjoy this Thanksgiving Leftover Turkey Sandwich. If you make it, please leave a rating or comment and share a photo with the hashtag #eatyourselfskinny—I love seeing your recreations!