No need to let Thanksgiving leftovers go to waste—turn them into the ultimate Leftover Thanksgiving Turkey Sandwich layered with tender turkey, salty prosciutto, creamy brie, and bright cranberry sauce.
Thanksgiving is over, guests have left, and your refrigerator is full of delicious leftovers. Instead of staring at tubs of turkey and cranberry sauce, make a simple, flavorful sandwich that tastes special without extra effort. This leftover turkey sandwich combines everyday holiday ingredients—leftover turkey, homemade-style cranberry sauce, thin prosciutto slices, creamy brie, and peppery arugula—stacked on hearty whole wheat or sprouted bread. It’s quick to assemble, delicious warm or cold, and perfect for using up those post-holiday bites.
To build the sandwich, think in layers. Toast two slices of bread if you like a little crunch. Spread cranberry sauce on each slice, then add slices of turkey and a few pieces of prosciutto for a salty contrast. Brie warmed briefly until soft becomes spreadable and adds a rich, silky texture that pairs wonderfully with the jam-like cranberry sauce and the savory meat. Finish with a handful of arugula for a peppery bite and season lightly with salt and pepper. The result is balance in every bite—sweet, salty, creamy, and fresh.
How to Make a Leftover Turkey Sandwich
Assembling this sandwich takes only minutes. Start by spreading cranberry sauce on both slices of bread so each bite has a touch of sweet-tart flavor. Layer leftover turkey breast slices on top, followed by thin prosciutto for a delicate, salty texture. Warm a few ounces of brie in the microwave for 5–10 seconds to soften it, then spread a thin layer over the meat. Add arugula for brightness and a sprinkle of salt and pepper if desired. Close the sandwich, slice, and enjoy.
If you prefer a warm, melty variation, press the sandwich on a grill pan or in a panini press until the brie is melted and the bread is golden. A quick press adds a crispy exterior and transforms the sandwich into a decadent grilled cheese-style treat—perfect for colder days or when you want something comforting.
More Holiday Side Dish Ideas
- Sausage, Apple and Herb Stuffing
- Holiday Glazed Acorn Squash with Pomegranates and Toasted Pine Nuts
- Cranberry Cocktail Meatballs
- Winter Kale and Quinoa Salad
- The Perfect Holiday Cheeseboard
- Lightened Up Green Bean Casserole
Enjoy this Thanksgiving Leftover Turkey Sandwich—and if you recreate it, please leave a review below and share how you customized it. I love seeing your versions and ideas!
Thanksgiving Leftover Turkey Sandwich
Prep Time: 10 mins
Total Time: 10 mins
Servings: 2
Ingredients
- 4 slices whole wheat or sprouted bread
- 1/4 cup cranberry sauce or jam
- 6–8 slices leftover turkey breast
- 4–6 slices prosciutto
- 4 ounces creamy brie, slightly melted or softened
- Handful of arugula
- Salt and pepper, to taste
Instructions
- Spread cranberry sauce on each slice of bread.
- Layer turkey breast slices over one slice of bread, then add prosciutto.
- Warm the brie for 5–10 seconds in the microwave to soften, or leave at room temperature until spreadable. Spread a thin layer of the softened brie over the turkey and prosciutto.
- Top with a handful of arugula and season with salt and pepper if desired.
- Close the sandwich, slice in half, and serve. Optional: grill the sandwich in a panini press or on a grill pan until the bread is golden and the brie is melted.